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Liquid Pharmaceuticals
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    Lines for Vials

    The manufacturing process for injection bottles typically begins with a compact system. This consists of a washing machine, a drying and sterilizing tunnel, a filling and sealing machine as well as overseal capping machine. Compact systems for injection bottles are finished using sterile room equipment (on-site sterile room) or in the innovative isolator technology (machine sterile room). The containers are checked, labeled and end-packaged on subsequent machines. Bosch provides an individually configurable range of machinery for this application for maximum production capacities of up to 36,000 containers per hour.

    Processing steps at a glance:

    Cleaning: reliable internal and external cleaning with the washing machines RRU, RRN, RQU DZ or RQN DZ.

    Sterilization: drying and sterilizing tunnel HQL for sterilization and depyprogenation by the laminar flow principle. At the outfeed end the containers are transferred in batches on to the infeed belt of the filling and sealing machine.

    Filling and pressing in stoppers: Filling and pressing in stoppers with filling and sealing machines MLF or FLP. (On the MLF machine caps can also be placed in position and oversealed).

    Oversealing: placing caps in position and low-particle oversealing with the overseal capping machine VRT or VRK.

    Subsequent processing steps:
    Check for particle freedom and cosmetic defects.
    Check injection bottles for impermeability with the inspection machine KLD.
    Application of a self-adhesive label with the labeling machine ERS.
    End packing of containers in thermoformed blisters, folding boxes and/or cartons cartoning machines.

    DS =SiV= 2003.